Gut microbiome diversity and composition is associated with hypertension in women.

ABSTRACT:

Objectives

Animal studies support a role for the gut microbiota in hypertension development, but large human studies are lacking. Here, we investigated the relationship between hypertension prevalence and gut microbial composition in two cohorts.

Methods

We included 871 unrelated TwinsUK women with faecal microbiome data (16s rRNA gene sequencing). Multivariable linear models adjusted for age, age2 and BMI as well as MiRKAT models, were used to estimate the association of hypertension with alpha- and beta-diversity metrics. To identify taxa associated with hypertension, a generalized additive model for location scale and shape was computed adjusting for covariates and multiple testing. Results were replicated in 448 women from PREDICT-1.

Results

We found that measures

SUBMITTER: Louca P 

PROVIDER: S-EPMC7611529 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature