Early symptoms in symptomatic and preclinical genetic frontotemporal lobar degeneration.

ABSTRACT:

Objectives

The clinical heterogeneity of frontotemporal dementia (FTD) complicates identification of biomarkers for clinical trials that may be sensitive during the prediagnostic stage. It is not known whether cognitive or behavioural changes during the preclinical period are predictive of genetic status or conversion to clinical FTD. The first objective was to evaluate the most frequent initial symptoms in patients with genetic FTD. The second objective was to evaluate whether preclinical mutation carriers demonstrate unique FTD-related symptoms relative to familial mutation non-carriers.

Methods

The current study used data from the Genetic Frontotemporal Dementia Initiative multicentre cohort study collected between 2012 and 2018. Participants included symptomatic carriers

SUBMITTER: Tavares TP 

PROVIDER: S-EPMC7611534 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature