In Situ Maturation and Tissue Adaptation of Type 2 Innate Lymphoid Cell Progenitors.

ABSTRACT: Innate lymphoid cells (ILCs) are generated early during ontogeny and persist predominantly as tissue-resident cells. Here, we examined how ILCs are maintained and renewed within tissues. We generated a single cell atlas of lung ILC2s and found that Il18r1⁺ ILCs comprise circulating and tissue-resident ILC progenitors (ILCP) and effector-cells with heterogeneous expression of the transcription factors Tcf7 and Zbtb16, and CD103. Our analyses revealed a continuous differentiation trajectory from Il18r1⁺ ST2^- ILCPs to Il18r^- ST2⁺ ILC2s, which was experimentally validated. Upon helminth infection, recruited and BM-derived cells generated the entire spectrum of ILC2s in parabiotic and shield chimeric mice, consistent with their potential ro

SUBMITTER: Zeis P 

PROVIDER: S-EPMC7611573 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature