Oxidative stress specifically inhibits replication of dengue virus.

ABSTRACT: Reactive oxygen species (ROS) are chemically active species which are involved in maintaining cellular and signalling processes at physiological concentrations. Therefore, cellular components that regulate redox balance are likely to play a crucial role in viral life-cycle either as promoters of viral replication or with antiviral functions. Zinc is an essential micronutrient associated with anti-oxidative systems and helps in maintaining a balanced cellular redox state. Here, we show that zinc chelation leads to induction of reactive oxygen species (ROS) in epithelial cells and addition of zinc restores ROS levels to basal state. Addition of ROS (H₂O₂) inhibited dengue virus (DENV) infection in a dose-dependent manner indicating that oxidative stress has adverse effe

SUBMITTER: Khan NA 

PROVIDER: S-EPMC7611606 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature