E2A Modulates Stemness, Metastasis, and Therapeutic Resistance of Breast Cancer.

ABSTRACT: Cancer stem cells (CSC) are considered responsible for tumor initiation, therapeutic resistance, and metastasis. A comprehensive knowledge of the mechanisms governing the acquisition and maintenance of cancer stemness is crucial for the development of new therapeutic approaches in oncology. E2A basic helix-loop-helix (bHLH) transcription factors are associated with epithelial-mesenchymal transition (EMT) and tumor progression, but knowledge of their functional contributions to cancer biology is still limited. Using a combination of in vivo and in vitro analyses in a novel PyMT-E2A conditional knockout mouse model and derived primary tumor cell lines, we report here an essential role of E2A in stemness, metastasis, and therapeutic resistance in breast cancer. Targeted deletion

SUBMITTER: Lopez-Menendez C 

PROVIDER: S-EPMC7611611 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature