Atopic dermatitis trajectories to age 8 years in the GUSTO cohort.

ABSTRACT:

Background

The heterogeneity of childhood atopic dermatitis (AD) underscores the need to understand latent phenotypes that may inform risk stratification and disease prognostication.

Objective

To identify AD trajectories across the first 8 years of life and investigate risk factors associated with each trajectory and their relationships with other comorbidities.

Methods

Data were collected prospectively from 1152 mother-offspring dyads in the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort from ages 3 months to 8 years. AD was defined based on parent-reported doctor's diagnosis. An unsupervised machine learning technique was used to determine AD trajectories.

Results

Three AD trajectories were identified as follows: early-onset transient (6.3%),

SUBMITTER: Suaini NHA 

PROVIDER: S-EPMC7611621 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature