Decoding myofibroblast origins in human kidney fibrosis.

ABSTRACT: Kidney fibrosis is the hallmark of chronic kidney disease progression; however, at present no antifibrotic therapies exist^1-3. The origin, functional heterogeneity and regulation of scar-forming cells that occur during human kidney fibrosis remain poorly understood^1,2,4. Here, using single-cell RNA sequencing, we profiled the transcriptomes of cells from the proximal and non-proximal tubules of healthy and fibrotic human kidneys to map the entire human kidney. This analysis enabled us to map all matrix-producing cells at high resolution, and to identify distinct subpopulations of pericytes and fibroblasts as the main cellular sources of scar-forming myofibroblasts during human kidney fibrosis. We used genetic fate-tracing, time-course single-cell RNA sequencing and AT

SUBMITTER: Kuppe C 

PROVIDER: S-EPMC7611626 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature