Cis-effects on gene expression in the human prenatal brain associated with genetic risk for neuropsychiatric disorders.

ABSTRACT: The majority of common risk alleles identified for neuropsychiatric disorders reside in noncoding regions of the genome and are therefore likely to impact gene regulation. However, the genes that are primarily affected and the nature and developmental timing of these effects remain unclear. Given the hypothesized role for early neurodevelopmental processes in these conditions, we here define genetic predictors of gene expression in the human fetal brain with which we perform transcriptome-wide association studies (TWASs) of attention deficit hyperactivity disorder (ADHD), autism spectrum disorder, bipolar disorder, major depressive disorder, and schizophrenia. We identify prenatal cis-regulatory effects on 63 genes and 166 individual transcripts associated with genetic risk for these condi

SUBMITTER: Hall LS 

PROVIDER: S-EPMC7611670 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature