Neurophysiological Correlates of Trait Impulsivity in Parkinson's Disease.

ABSTRACT:

Background

Impulsivity is common in people with Parkinson's disease (PD), with many developing impulsive compulsive behavior disorders (ICB). Its pathophysiological basis remains unclear.

Objectives

We aimed to investigate local field potential (LFP) markers of trait impulsivity in PD and their relationship to ICB.

Methods

We recorded subthalamic nucleus (STN) LFPs in 23 PD patients undergoing deep brain stimulation implantation. Presence and severity of ICB were assessed by clinical interview and the Questionnaire for Impulsive-Compulsive Disorders in PD-Rating Scale (QUIP-RS), whereas trait impulsivity was estimated with the Barratt Impulsivity Scale (BIS-11). Recordings were obtained during the off dopaminergic states and the power spectrum of the subthalamic activ

SUBMITTER: Ricciardi L 

PROVIDER: S-EPMC7611688 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature