Soluble biomarkers associated with chronic lung disease in older children and adolescents with perinatal HIV infection.

ABSTRACT:

Objective

HIV-associated chronic lung disease (HCLD) is a common comorbidity in children and adolescents in sub-Saharan Africa (SSA). The pathogenesis of HCLD is unclear and may be driven by underlying dysregulated systemic immune activation and inflammation. We investigated the association between 26 plasma soluble biomarkers and HCLD.

Design

Case--control analysis of baseline biomarker data from 336 children and adolescents (6-19 years old) with perinatal HIV infection (PHIV) and HCLD (cases) and 74 age-matched and sex-matched controls with PHIV but no CLD. HCLD was defined as having a forced expiratory volume in one second (FEV1) z score less than -1 with no reversibility.

Methods

Cryopreserved plasma collected at recruitment was used in a multiplex bead assay (Lum

SUBMITTER: Hameiri-Bowen D 

PROVIDER: S-EPMC7611698 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature