SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation.

ABSTRACT: Macrophages exhibit a spectrum of activation states ranging from classical to alternative activation¹. Alternatively, activated macrophages are involved in diverse pathophysiological processes such as confining tissue parasites², improving insulin sensitivity³ or promoting an immune-tolerant microenvironment that facilitates tumour growth and metastasis⁴. Recently, the metabolic regulation of macrophage function has come into focus as both the classical and alternative activation programmes require specific regulated metabolic reprogramming⁵. While most of the studies regarding immunometabolism have focussed on the catabolic pathways activated to provide energy, little is known about the anabolic pathways mediating macrophage alternati

SUBMITTER: Bidault G 

PROVIDER: S-EPMC7611716 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature