Sarcopenia Definitions as Predictors of Fracture Risk Independent of FRAX^® , Falls, and BMD in the Osteoporotic Fractures in Men (MrOS) Study: A Meta-Analysis.

ABSTRACT: Dual-energy X-ray absorptiometry (DXA)-derived appendicular lean mass/height² (ALM/ht² ) is the most commonly used estimate of muscle mass in the assessment of sarcopenia, but its predictive value for fracture is substantially attenuated by femoral neck (fn) bone mineral density (BMD). We investigated predictive value of 11 sarcopenia definitions for incident fracture, independent of fnBMD, fracture risk assessment tool (FRAX^® ) probability, and prior falls, using an extension of Poisson regression in US, Sweden, and Hong Kong Osteoporois Fractures in Men Study (MrOS) cohorts. Definitions tested were those of Baumgartner and Delmonico (ALM/ht² only), Morley, the International Working Group on Sarcopenia, European Working Group on Sarcopenia in Ol

SUBMITTER: Harvey NC 

PROVIDER: S-EPMC7611727 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature