Level and change in bone microarchitectural parameters and their relationship with previous fracture and established bone mineral density loci.

ABSTRACT:

Background

Osteoporosis is characterised by a reduction of bone mineral density (BMD) and predisposition to fracture. Bone microarchitecture, measured by high resolution peripheral quantitative computed tomography (HR-pQCT), has been related to fragility fractures and BMD and has been the subject of large-scale genome-wide analysis. We investigated whether fracture was related to baseline values and longitudinal changes in bone microarchitecture and whether bone microarchitecture was associated with established BMD loci.

Methods

115 males and 99 females (aged 72-81 at baseline) from the Hertfordshire Cohort Study (HCS) were analysed. Fracture history was determined in 2011-2012 by self-report and vertebral fracture assessment. Participants underwent HR-pQCT scans of the dist

SUBMITTER: Fuggle NR 

PROVIDER: S-EPMC7611749 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature