Role of maternal tryptophan metabolism in allergic diseases in the offspring.

ABSTRACT:

Background

Nicotinamide (vitamin B3) is a metabolite of tryptophan and dietary precursor of enzymes involved in many regulatory processes, which may influence fetal immune development.

Objective

We examined whether maternal plasma concentrations of nicotinamide, tryptophan or nine related tryptophan metabolites during pregnancy were associated with the risk of development of infant eczema, wheeze, rhinitis or allergic sensitization.

Methods

In the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) study, we analysed the associations between maternal plasma levels of nicotinamide, tryptophan and tryptophan metabolites at 26-28 weeks of gestation and allergic outcomes collected through interviewer-administered questionnaires at multiple time-points and skin prick

SUBMITTER: Lau HX 

PROVIDER: S-EPMC7611755 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature