Effector differentiation downstream of lineage commitment in ILC1s is driven by Hobit across tissues.

ABSTRACT: Innate lymphoid cells (ILCs) participate in tissue homeostasis, inflammation, and early immunity against infection. It is unclear how ILCs acquire effector function and whether these mechanisms differ between organs. Through multiplexed single-cell mRNA sequencing, we identified cKit⁺CD127^hiTCF-1^hi early differentiation stages of T-bet⁺ ILC1s. These cells were present across different organs and had the potential to mature toward CD127^intTCF-1^int and CD127^-TCF-1^- ILC1s. Paralleling a gradual loss of TCF-1, differentiating ILC1s forfeited their expansion potential while increasing expression of effector molecules, reminiscent of T cell differentiation in secondary lymphoid organs. The transcription facto

SUBMITTER: Friedrich C 

PROVIDER: S-EPMC7611762 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature