A computationally efficient physiologically comprehensive 3D-0D closed-loop model of the heart and circulation.

ABSTRACT: Computer models of cardiac electro-mechanics (EM) show promise as an effective means for the quantitative analysis of clinical data and, potentially, for predicting therapeutic responses. To realize such advanced applications methodological key challenges must be addressed. Enhanced computational efficiency and robustness is crucial to facilitate, within tractable time frames, model personalization, the simulation of prolonged observation periods under a broad range of conditions, and physiological completeness encompassing therapy-relevant mechanisms is needed to endow models with predictive capabilities beyond the mere replication of observations. Here, we introduce a universal feature-complete cardiac EM modeling framework that builds on a flexible method for coupling a 3D model of bi-v

SUBMITTER: Augustin CM 

PROVIDER: S-EPMC7611781 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature