In silico optimization of targeted aerosol delivery in upper airways via Inhaled Volume Tracking.

ABSTRACT:

Background

Despite the widespread use of aerosol inhalation as a drug delivery method, targeted delivery to the upper airways remains an ongoing challenge in the quest for improved clinical response in respiratory disease.

Methods

Here, we examine in silico flow and particle dynamics when using an oral Inhaled Volume Tracking manoeuvre. A short pulsed aerosol bolus is injected during slow inhalation flow rates followed by clean air, and a breath-hold is initiated once it reaches the desired depth. We explore the fate of a broad particle size range (1-40 μm) for both upright and supine positions.

Findings

Our findings illustrate that despite attempts to mitigate dispersion using slower flow rates, the laryngeal jet disperses the aerosol bolus and thus remains a hurdle

SUBMITTER: Heller-Algazi M 

PROVIDER: S-EPMC7611794 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature