Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis.

ABSTRACT:

Background & aims

To influence host and disease phenotype, compositional microbiome changes, which have been demonstrated in patients with primary sclerosing cholangitis (PSC), must be accompanied by functional changes. We therefore aimed to characterize the genetic potential of the gut microbiome in patients with PSC compared with healthy controls (HCs) and patients with inflammatory bowel disease (IBD).

Methods

Fecal DNA from 2 cohorts (1 Norwegian and 1 German), in total comprising 136 patients with PSC (58% with IBD), 158 HCs, and 93 patients with IBD without PSC, were subjected to metagenomic shotgun sequencing, generating 17 billion paired-end sequences, which were processed using HUMAnN2 and MetaPhlAn2, and analyzed using generalized linear models and random effects m

SUBMITTER: Kummen M 

PROVIDER: S-EPMC7611822 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature