Astrocytes contribute to remote memory formation by modulating hippocampal-cortical communication during learning.

ABSTRACT: Remote memories depend on coordinated activity in the hippocampus and frontal cortices, but the timeline of these interactions is debated. Astrocytes sense and modify neuronal activity, but their role in remote memory is scarcely explored. We expressed the G_i-coupled designer receptor hM4Di in CA1 astrocytes and discovered that astrocytic manipulation during learning specifically impaired remote, but not recent, memory recall and decreased activity in the anterior cingulate cortex (ACC) during retrieval. We revealed massive recruitment of ACC-projecting CA1 neurons during memory acquisition, which was accompanied by the activation of ACC neurons. Astrocytic G_i activation disrupted CA3 to CA1 communication in vivo and reduced the downstream response in the ACC. In beha

SUBMITTER: Kol A 

PROVIDER: S-EPMC7611962 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature