Ontology highlight
ABSTRACT:
SUBMITTER: Mahn M
PROVIDER: S-EPMC7611984 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Mahn Mathias M Saraf-Sinik Inbar I Patil Pritish P Pulin Mauro M Bitton Eyal E Karalis Nikolaos N Bruentgens Felicitas F Palgi Shaked S Gat Asaf A Dine Julien J Wietek Jonas J Davidi Ido I Levy Rivka R Litvin Anna A Zhou Fangmin F Sauter Kathrin K Soba Peter P Schmitz Dietmar D Lüthi Andreas A Rost Benjamin R BR Wiegert J Simon JS Yizhar Ofer O
Neuron 20210511 10
Information is carried between brain regions through neurotransmitter release from axonal presynaptic terminals. Understanding the functional roles of defined neuronal projection pathways requires temporally precise manipulation of their activity. However, existing inhibitory optogenetic tools have low efficacy and off-target effects when applied to presynaptic terminals, while chemogenetic tools are difficult to control in space and time. Here, we show that a targeting-enhanced mosquito homolog ...[more]