Multiplex Serum Biomarker Assays Improve Prediction of Renal and Mortality Outcomes in Chronic Kidney Disease.

ABSTRACT:

Background

We investigated the predictive value of 11 serum biomarkers for renal and mortality end points in people with CKD.

Methods

Adults with CKD (n=139) were enrolled from outpatient clinics between February 2014 and November 2016. Biomarker quantification was performed using two multiplex arrays on a clinical-grade analyzer. Relationships between biomarkers and renal and mortality end points were investigated by random forests and Cox proportional hazards regression.

Results

The cohort was 56% male. The mean age was 63 years and median (IQR) CKD-EPI eGFR was 33 (24-51) ml/min per BSA. A total of 56 (40%) people developed a composite end point defined as ≥40% decline in eGFR, doubling of serum creatinine, RRT, or death over median (IQR) follow-up of 5.4 (4

SUBMITTER: Martin WP 

PROVIDER: S-EPMC7612046 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature