Ontology highlight
ABSTRACT:
SUBMITTER: Crowther JM
PROVIDER: S-EPMC7612104 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Crowther Jennifer M JM Gilmour Letitia H LH Porebski Benjamin T BT Heath Sarah G SG Pattinson Neil R NR Owen Maurice C MC Fredericks Rayleen R Buckle Ashley M AM Fee Conan J CJ Göbl Christoph C Dobson Renwick C J RCJ
The Biochemical journal 20210901 17
Angiotensinogen fine-tunes the tightly controlled activity of the renin-angiotensin system by modulating the release of angiotensin peptides that control blood pressure. One mechanism by which this modulation is achieved is via angiotensinogen's Cys18-Cys138 disulfide bond that acts as a redox switch. Molecular dynamics simulations of each redox state of angiotensinogen reveal subtle dynamic differences between the reduced and oxidised forms, particularly at the N-terminus. Surface plasmon reson ...[more]