Biophysical and morphological changes in inner hair cells and their efferent innervation in the ageing mouse cochlea.

ABSTRACT:

Key points

Age-related hearing loss is a progressive hearing loss involving environmental and genetic factors, leading to a decrease in hearing sensitivity, threshold and speech discrimination. We compared age-related changes in inner hair cells (IHCs) between four mouse strains with different levels of progressive hearing loss. The surface area of apical coil IHCs (9-12 kHz cochlear region) decreases by about 30-40% with age. The number of BK channels progressively decreases with age in the IHCs from most mouse strains, but the basolateral membrane current profile remains unchanged. The mechanoelectrical transducer current is smaller in mice harbouring the hypomorphic Cdh23 allele Cdh23^ahl (C57BL/6J; C57BL/6NTac), but not in Cdh23-repaired mice (C57BL/6NTac^Cdh23+</

SUBMITTER: Jeng JY 

PROVIDER: S-EPMC7612127 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature