Ontology highlight
ABSTRACT:
SUBMITTER: Celus W
PROVIDER: S-EPMC7612191 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Celus Ward W Oliveira Ana I AI Rivis Silvia S Van Acker Heleen H HH Landeloos Ewout E Serneels Jens J Cafarello Sarah Trusso ST Van Herck Yannick Y Mastrantonio Roberta R Köhler Arnaud A Garg Abhishek D AD Flamand Véronique V Tamagnone Luca L Marine Jean-Christophe JC Di Matteo Mario M Costa Bruno M BM Bechter Oliver O Mazzone Massimiliano M
Cancer immunology research 20211123 1
Cytotoxic T cell (CTL) infiltration of the tumor carries the potential to limit cancer progression, but their exclusion by the immunosuppressive tumor microenvironment hampers the efficiency of immunotherapy. Here, we show that expression of the axon guidance molecule Plexin-A4 (<i>Plxna4</i>) in CTLs, especially in effector/memory CD8<sup>+</sup> T cells, is induced upon T-cell activation, sustained in the circulation, but reduced when entering the tumor bed. Therefore, we deleted <i>Plxna4</i> ...[more]