Trial of Three Rounds of Mass Azithromycin Administration for Yaws Eradication.

ABSTRACT:

Background

Treponema pallidum subspecies pertenue causes yaws. Strategies to better control, eliminate, and eradicate yaws are needed.

Methods

In an open-label, cluster-randomized, community-based trial conducted in a yaws-endemic area of Papua New Guinea, we randomly assigned 38 wards (i.e., clusters) to receive one round of mass administration of azithromycin followed by two rounds of target treatment of active cases (control group) or three rounds of mass administration of azithromycin (experimental group); round 1 was administered at baseline, round 2 at 6 months, and round 3 at 12 months. The coprimary end points were the prevalence of active cases of yaws, confirmed by polymerase-chain-reaction assay, in the entire trial population and the prevalence of l

SUBMITTER: John LN 

PROVIDER: S-EPMC7612200 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature