Atopic Eczema-Associated Fracture Risk and Oral Corticosteroids: A Population-Based Cohort Study.

ABSTRACT:

Background

Evidence suggests adults with atopic eczema have increased fracture risk. However, it is unclear whether oral corticosteroids explain the association.

Objective

To assess to what extent oral corticosteroids mediate the relationship between atopic eczema and fractures.

Methods

We conducted a cohort study using English primary care (Clinical Practice Research Datalink) and hospital admissions (Hospital Episode Statistics) records (1998-2016) including adults (18 years old and older) with atopic eczema matched (age, sex, and general practice) with up to 5 adults without atopic eczema. We used Cox regression to estimate hazard ratios (HRs) for specific major osteoporotic fractures (hip, spine, pelvis, or wrist) and for any-site fracture comparing individuals wi

SUBMITTER: Matthewman J 

PROVIDER: S-EPMC7612204 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature