PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation.

ABSTRACT: Cytokinetic membrane abscission is a spatially and temporally regulated process that requires ESCRT (endosomal sorting complexes required for transport)–dependent control of membrane remodeling at the midbody, a subcellular organelle that defines the cleavage site. Alteration of ESCRT function can lead to cataract, but the underlying mechanism and its relation to cytokinesis are unclear. We found a lens-specific cytokinetic process that required PI3K-C2α (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2α), its lipid product PI(3,4)P₂ (phosphatidylinositol 3,4-bisphosphate), and the PI(3,4)P₂–binding ESCRT-II subunit VPS36 (vacuolar protein-sorting-associated protein 36). Loss of each of these components led to impaired cytokinesis, triggering prematu

SUBMITTER: Gulluni F 

PROVIDER: S-EPMC7612254 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature