Copeptin as a marker of atherosclerosis and arteriosclerosis.

ABSTRACT:

Background and aims

The precursor peptide of vasopressin, copeptin, has previously been linked to increased risk of developing diabetes mellitus, coronary artery disease and cardiovascular mortality. Whether elevated copeptin is associated with markers of atherosclerosis and arteriosclerosis in the general population is not known.

Methods

In this population-based, cross-sectional study, coronary artery calcium score (CACS), carotid-femoral pulse wave velocity (c-f PWV) and fasting plasma copeptin were measured in 5303 individuals in the Swedish cardiopulmonary bioimage study (SCAPIS). Multivariable logistic regression models were used to analyze the associations between copeptin and high CACS (>100) and high c-f PWV (>10 m/s), respectively.

Results

The number of indiv

SUBMITTER: Schill F 

PROVIDER: S-EPMC7612343 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature