Systemic inflammatory markers in neuropathic pain, nerve injury, and recovery.

ABSTRACT:

Abstract

The role that inflammation plays in human nerve injury and neuropathic pain is incompletely understood. Previous studies highlight the role of inflammation in the generation and maintenance of neuropathic pain, but the emerging evidence from the preclinical literature for its role in the resolution of neuropathic pain remains to be explored in humans. Here, we use carpal tunnel syndrome (CTS) as a human model system of nerve injury and neuropathic pain to determine changes in serum cytokine protein levels and gene expression levels before (active stage of disease) and after carpal tunnel decompression surgery (recovery). Fifty-five patients with CTS were studied, and 21 healthy age-matched and gender-matched participants served as controls. In the active stage of the disea

SUBMITTER: Sandy-Hindmarch O 

PROVIDER: S-EPMC7612369 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature