Regular Acetaminophen Use and Blood Pressure in People With Hypertension: The PATH-BP Trial.

ABSTRACT:

Background

Acetaminophen is widely used as first-line therapy for chronic pain because of its perceived safety and the assumption that, unlike nonsteroidal anti-inflammatory drugs, it has little or no effect on blood pressure (BP). Although observational studies suggest that acetaminophen may increase BP, clinical trials are lacking. We, therefore, studied the effects of regular acetaminophen dosing on BP in individuals with hypertension.

Methods

In this double-blind, placebo-controlled, crossover study, 110 individuals were randomized to receive 1 g acetaminophen 4× daily or matched placebo for 2 weeks followed by a 2-week washout period before crossing over to the alternate treatment. At the beginning and end of each treatment period, 24-hour ambulatory BPs were measured.

SUBMITTER: MacIntyre IM 

PROVIDER: S-EPMC7612370 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature