Ontology highlight
ABSTRACT:
SUBMITTER: Guerrero Llobet S
PROVIDER: S-EPMC7612401 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Guerrero Llobet Sergi S Bhattacharya Arkajyoti A Everts Marieke M Kok Klaas K van der Vegt Bert B Fehrmann Rudolf S N RSN van Vugt Marcel A T M MATM
Oncogene 20220129 8
Oncogene-induced replication stress characterizes many aggressive cancers. Several treatments are being developed that target replication stress, however, identification of tumors with high levels of replication stress remains challenging. We describe a gene expression signature of oncogene-induced replication stress. A panel of triple-negative breast cancer (TNBC) and non-transformed cell lines were engineered to overexpress CDC25A, CCNE1 or MYC, which resulted in slower replication kinetics. R ...[more]