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Differential impact of COVID-19 in pregnant women from high-income countries and low- to middle-income countries: A systematic review and meta-analysis.


ABSTRACT:

Background

SARS-CoV-2 has infected a large number of pregnant women.

Objective

To compare clinical, perinatal outcomes of women with COVID-19 from high-income countries (HICs) and low- to middle-income countries (LMICs).

Search strategy

Online databases were searched.

Selection criteria

Original studies on pregnant women with COVID-19 were included.

Data collection and analysis

Information on clinical presentation, co-morbidities, pregnancy outcomes, neonatal outcomes, and SARS-CoV-2 infection in neonates was extracted.

Main results

The pooled estimate of SARS-CoV-2 positive neonates is 3.7%. Symptomatic presentations are less common in LMICs compared to HICs (odds ratio [OR] 0.38). Diabetes (OR 0.5), hypertension (OR 0.5), and asthma (OR 0.14) are commonly reported from HICs; hypothyroidism (OR 2.2), anemia (OR 3.2), and co-infections (OR 6.0) are commonly reported in LMICs. The overall risk of adverse pregnancy outcomes is higher in LMICs compared to HICs (OR 2.4). Abortion (OR 6.2), stillbirths (OR 2.0), and maternal death (OR 7.8) are more common in LMICs. Preterm births and premature rupture of membranes are comparable in both groups. Neonatal deaths (OR 3.7), pneumonia (OR 7.5), and neonatal SARS-CoV-2 infection (OR 1.8) are commonly reported in LMICs.

Conclusions

In LMICs, pregnant women and neonates are more vulnerable to adverse outcomes due to COVID-19. PROSPERO registration no: CRD42020198743.

SUBMITTER: Gajbhiye RK 

PROVIDER: S-EPMC7612435 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Publications

Differential impact of COVID-19 in pregnant women from high-income countries and low- to middle-income countries: A systematic review and meta-analysis.

Gajbhiye Rahul K RK   Sawant Mamta S MS   Kuppusamy Periyasamy P   Surve Suchitra S   Pasi Achhelal A   Prusty Ranjan K RK   Mahale Smita D SD   Modi Deepak N DN  

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20210714 1


<h4>Background</h4>SARS-CoV-2 has infected a large number of pregnant women.<h4>Objective</h4>To compare clinical, perinatal outcomes of women with COVID-19 from high-income countries (HICs) and low- to middle-income countries (LMICs).<h4>Search strategy</h4>Online databases were searched.<h4>Selection criteria</h4>Original studies on pregnant women with COVID-19 were included.<h4>Data collection and analysis</h4>Information on clinical presentation, co-morbidities, pregnancy outcomes, neonatal  ...[more]

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