Clinical Evaluation of the Polygenetic Background of Blood Pressure in the Population-Based Setting.

ABSTRACT: The clinical value of the polygenetic component of blood pressure (BP) is commonly questioned. We evaluated a genetic risk score for BP (BP-GRS₈₅₈), based on the most recently published genome-wide association studies variants that were significantly associated with either systolic BP or diastolic BP, for prediction of hypertension and cardiovascular end points. The genotyping was performed in 2 urban-based prospective cohorts: the Malmö Diet and Cancer (n=29 295) and the Malmö Preventive Project (n=9367) and a weighted BP-GRS₈₅₈ based on 858 SNPs was calculated. At baseline, we found a difference of 9.0 mm Hg (systolic BP) and 4.8 mm Hg (diastolic BP) between the top and the bottom quartile of BP-GRS₈₅₈. In Malmö Preventive Project, the top versus bottom q

SUBMITTER: Giontella A 

PROVIDER: S-EPMC7612446 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature