Inhibition of Collagenase Q1 of <i>Bacillus cereus</i> as a Novel Antivirulence Strategy for the Treatment of Skin-Wound Infections.

ABSTRACT: Despite the progress in surgical techniques and antibiotic prophylaxis, opportunistic wound infections with Bacillus cereus remain a public health problem. Secreted toxins are one of the main factors contributing to B. cereus pathogenicity. A promising strategy to treat such infections is to target these toxins and not the bacteria. Although the exoenzymes produced by B. cereus are thoroughly investigated, little is known about the role of B. cereus collagenases in wound infections. In this report, the collagenolytic activity of secreted collagenases (Col) is characterized in the B. cereus culture supernatant (csn) and its isolated recombinantly produced ColQ1 is characterized. The data reveals that ColQ1 causes damage on derma

SUBMITTER: Alhayek A 

PROVIDER: S-EPMC7612511 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature