An automated method for precise axon reconstruction from recordings of high-density micro-electrode arrays.

ABSTRACT: Objective:Neurons communicate with each other by sending action potentials (APs) through their axons. The velocity of axonal signal propagation describes how fast electrical APs can travel. This velocity can be affected in a human brain by several pathologies, including multiple sclerosis, traumatic brain injury and channelopathies. High-density microelectrode arrays (HD-MEAs) provide unprecedented spatio-temporal resolution to extracellularly record neural electrical activity. The high density of the recording electrodes enables to image the activity of individual neurons down to subcellular resolution, which includes the propagation of axonal signals. However, axon reconstruction, to date, mainly relies on manual approaches to select the electrodes and channels that seemingly reco

SUBMITTER: Buccino AP 

PROVIDER: S-EPMC7612575 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature