A predictive algorithm for identifying children with sickle cell anemia among children admitted to hospital with severe anemia in Africa.

ABSTRACT: Sickle cell anemia (SCA) is common in sub-Saharan Africa where approximately 1% of births are affected. Severe anemia is a common cause for hospital admission within the region yet few studies have investigated the contribution made by SCA. The Transfusion and Treatment of severe anemia in African Children Trial (ISRCTN84086586) investigated various treatment strategies in 3983 children admitted with severe anemia (hemoglobin < 6.0 g/dl) based on two severity strata to four hospitals in Africa (three Uganda and one Malawi). Children with known-SCA were excluded from the uncomplicated stratum and capped at 25% in the complicated stratum. All participants were genotyped for SCA at trial completion. SCA was rare in Malawi (six patients overall), so here we focus on the participants recruited

SUBMITTER: Olupot-Olupot P 

PROVIDER: S-EPMC7612591 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature