Response adaptive intervention allocation in stepped-wedge cluster randomized trials.

ABSTRACT:

Background

Stepped-wedge cluster randomized trial (SW-CRT) designs are often used when there is a desire to provide an intervention to all enrolled clusters, because of a belief that it will be effective. However, given there should be equipoise at trial commencement, there has been discussion around whether a pre-trial decision to provide the intervention to all clusters is appropriate. In pharmaceutical drug development, a solution to a similar desire to provide more patients with an effective treatment is to use a response adaptive (RA) design.

Methods

We introduce a way in which RA design could be incorporated in an SW-CRT, permitting modification of the intervention allocation during the trial. The proposed framework explicitly permits a balance to be sought between pow

SUBMITTER: Grayling MJ 

PROVIDER: S-EPMC7612601 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature