Replicative history marks transcriptional and functional disparity in the CD8⁺ T cell memory pool.

ABSTRACT: Clonal expansion is a core aspect of T cell immunity. However, little is known with respect to the relationship between replicative history and the formation of distinct CD8⁺ memory T cell subgroups. To address this issue, we developed a genetic-tracing approach, termed the DivisionRecorder, that reports the extent of past proliferation of cell pools in vivo. Using this system to genetically 'record' the replicative history of different CD8⁺ T cell populations throughout a pathogen-specific immune response, we demonstrate that the central memory T (T_CM) cell pool is marked by a higher number of prior divisions than the effector memory T cell pool, owing to the combination of strong proliferative activity during the acute immune response and selective prolif

SUBMITTER: Bresser K 

PROVIDER: S-EPMC7612726 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature