Ontology highlight
ABSTRACT:
SUBMITTER: Pellicano G
PROVIDER: S-EPMC7612761 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Pellicanò Grazia G Al Mamun Mohammed M Jurado-Santiago Dolores D Villa-Hernández Sara S Yin Xingyu X Giannattasio Michele M Lanz Michael C MC Smolka Marcus B MB Yeeles Joseph J Shirahige Katsuhiko K García-Díaz Miguel M Bermejo Rodrigo R
Molecular cell 20210430 13
DNA polymerase ε (Polε) carries out high-fidelity leading strand synthesis owing to its exonuclease activity. Polε polymerase and exonuclease activities are balanced, because of partitioning of nascent DNA strands between catalytic sites, so that net resection occurs when synthesis is impaired. In vivo, DNA synthesis stalling activates replication checkpoint kinases, which act to preserve the functional integrity of replication forks. We show that stalled Polε drives nascent strand resection cau ...[more]