Generalisations of a Bayesian decision-theoretic randomisation procedure and the impact of delayed responses.

ABSTRACT: The design of sequential experiments and, in particular, randomised controlled trials involves a trade-off between operational characteristics such as statistical power, estimation bias and patient benefit. The family of randomisation procedures referred to as Constrained Randomised Dynamic Programming (CRDP), which is set in the Bayesian decision-theoretic framework, can be used to balance these competing objectives. A generalisation and novel interpretation of CRDP is proposed to highlight its inherent flexibility to adapt to a variety of practicalities and align with individual trial objectives. CRDP, as with most response-adaptive randomisation procedures, hinges on the limiting assumption of patient responses being available before allocation of the next patient. This forms one of the

SUBMITTER: Williamson SF 

PROVIDER: S-EPMC7612844 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature