Enhancer-gene specificity in development and disease.
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ABSTRACT:
SUBMITTER: Pachano T
PROVIDER: S-EPMC7612879 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Publications
Enhancer-gene specificity in development and disease.
Pachano Tomás T Haro Endika E Rada-Iglesias Alvaro A
Development (Cambridge, England) 20220610 11
Enhancers control the establishment of spatiotemporal gene expression patterns throughout development. Over the past decade, the development of new technologies has improved our capacity to link enhancers with their target genes based on their colocalization within the same topological domains. However, the mechanisms that regulate how enhancers specifically activate some genes but not others within a given domain remain unclear. In this Review, we discuss recent insights into the factors contro ...[more]
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