Use of contraceptives and risk of inflammatory bowel disease: a nested case-control study.

ABSTRACT:

Background

How contraceptive formulation, dose, duration of therapy and mode of delivery affects the risk of inflammatory bowel disease (IBD) is poorly described.

Aim

To examine associations between types of hormonal contraception and development of IBD.

Methods

This was a nested case-control study using IQVIA Medical Research Data. Women aged 15-49 years with a new diagnosis of IBD were matched with up to six controls by age, practice and year. Odds ratios (OR) and 95% confidence intervals (95% CI) for incident IBD and use of contraception were calculated.

Results

4932 incident cases of IBD were matched to 29 340 controls. Use of combined oral contraceptive pills (COCPs) was associated with the development of Crohn's disease and ulcerative colitis (OR 1.60 [1.

SUBMITTER: Pasvol TJ 

PROVIDER: S-EPMC7612921 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature