Smoking and infertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study.

ABSTRACT:

Objective

To investigate the association between smoking and infertility.

Design

Prospective study.

Setting

Nationwide cohort.

Patients

28,606 women and 27,096 men with questionnaire and genotype information from the Norwegian Mother, Father, and Child Cohort Study.

Intervention

Self-reported information on smoking (having ever smoked [both sexes], age at initiation [women only], cessation [women only], and cigarettes/week in current smokers [both sexes]) was gathered. Genetically predetermined levels or likelihood of presenting these traits were estimated for Mendelian randomization.

Main outcome measure

Infertility (time-to-pregnancy ≥12 months).

Results

Having ever smoked was unrelated to infertility in women or men. Higher smoking inten

SUBMITTER: Hernaez A 

PROVIDER: S-EPMC7612999 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature