Erythrocyte haemotoxicity profiling of snake venom toxins after nanofractionation.

ABSTRACT: Snakebite is classified as a priority Neglected Tropical Disease by the World Health Organization. Understanding the pathology of individual snake venom toxins is of great importance when developing more effective snakebite therapies. Snake venoms may induce a range of pathologies, including haemolytic activity. Although snake venom-induced erythrocyte lysis is not the primary cause of mortality, haemolytic activity can greatly debilitate victims and contributes to systemic haemotoxicity. Current assays designed for studying haemolytic activity are not suitable for rapid screening of large numbers of toxic compounds. Consequently, in this study, a high-throughput haemolytic assay was developed that allows profiling of erythrocyte lysis, and was validated using venom from a number of medica

SUBMITTER: Xie C 

PROVIDER: S-EPMC7613003 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature