Impaired brain glymphatic flow in experimental hepatic encephalopathy.

ABSTRACT:

Background & aims

Neuronal function is exquisitely sensitive to alterations in the extracellular environment. In patients with hepatic encephalopathy (HE), accumulation of metabolic waste products and noxious substances in the interstitial fluid of the brain is thought to result from liver disease and may contribute to neuronal dysfunction and cognitive impairment. This study was designed to test the hypothesis that the accumulation of these substances, such as bile acids, may result from reduced clearance from the brain.

Methods

In a rat model of chronic liver disease with minimal HE (the bile duct ligation [BDL] model), we used emerging dynamic contrast-enhanced MRI and mass-spectroscopy techniques to assess the efficacy of the glymphatic system, which facilitates clearanc

SUBMITTER: Hadjihambi A 

PROVIDER: S-EPMC7613052 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature