Segregation and integration of the functional connectome in neurodevelopmentally 'at risk' children.

ABSTRACT: Functional connectivity within and between Intrinsic Connectivity Networks (ICNs) transforms over development and is thought to support high order cognitive functions. But how variable is this process, and does it diverge with altered cognitive development? We investigated age-related changes in integration and segregation within and between ICNs in neurodevelopmentally 'at-risk' children, identified by practitioners as experiencing cognitive difficulties in attention, learning, language, or memory. In our analysis we used performance on a battery of 10 cognitive tasks alongside resting-state functional magnetic resonance imaging in 175 at-risk children and 62 comparison children aged 5-16. We observed significant age-by-group interactions in functional connectivity between two network pai

SUBMITTER: Jones JS 

PROVIDER: S-EPMC7613070 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature