Alterations in the metabolic and cardiorespiratory response to exercise in Huntington's Disease.

ABSTRACT:

Background

Limited data suggests that an altered metabolic and cardiorespiratory exercise response may affect exercise performance in individuals with Huntington's disease (HD). There is no clear exploration of the response in individuals at different stages of the disease or in relation to genetic markers. This study aimed to examine the exercise response and recovery of HD participants, and the relationship to genetic and clinical markers.

Method

HD gene-positive participants (n = 31; 9 pre-manifest; 22 manifest HD) and a healthy control group (n = 29) performed an incremental exercise test until exhaustion. Performance, cardiorespiratory, metabolic and perceptual responses to exercise were determined from a maximal cycle ergometer test throughout the exercise test and dur

SUBMITTER: Steventon JJ 

PROVIDER: S-EPMC7613076 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature