Ontology highlight
ABSTRACT:
SUBMITTER: Hidalgo-Mazzei D
PROVIDER: S-EPMC7613090 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Hidalgo-Mazzei Diego D Berk Michael M Cipriani Andrea A Cleare Anthony J AJ Florio Arianna Di AD Dietch Daniel D Geddes John R JR Goodwin Guy M GM Grunze Heinz H Hayes Joseph F JF Jones Ian I Kasper Siegfried S Macritchie Karine K McAllister-Williams R Hamish RH Morriss Richard R Nayrouz Sam S Pappa Sofia S Soares Jair C JC Smith Daniel J DJ Suppes Trisha T Talbot Peter P Vieta Eduard E Watson Stuart S Yatham Lakshmi N LN Young Allan H AH Stokes Paul R A PRA
The British journal of psychiatry : the journal of mental science 20181206 1
<h4>Background</h4>Most people with bipolar disorder spend a significant percentage of their lifetime experiencing either subsyndromal depressive symptoms or major depressive episodes, which contribute greatly to the high levels of disability and mortality associated with the disorder. Despite the importance of bipolar depression, there are only a small number of recognised treatment options available. Consecutive treatment failures can quickly exhaust these options leading to treatment-resistan ...[more]