Mapping the pharmacological modulation of brain oxygen metabolism: The effects of caffeine on absolute CMRO₂ measured using dual calibrated fMRI.

ABSTRACT: This study aims to map the acute effects of caffeine ingestion on grey matter oxygen metabolism and haemodynamics with a novel MRI method. Sixteen healthy caffeine consumers (8 males, age=24.7±5.1) were recruited to this randomised, double-blind, placebo-controlled study. Each participant was scanned on two days before and after the delivery of an oral caffeine (250mg) or placebo capsule. Our measurements were obtained with a newly proposed estimation approach applied to data from a dual calibration fMRI experiment that uses hypercapnia and hyperoxia to modulate brain blood flow and oxygenation. Estimates were based on a forward model that describes analytically the contributions of cerebral blood flow (CBF) and of the measured end-tidal partial pressures of CO₂ and O₂

SUBMITTER: Merola A 

PROVIDER: S-EPMC7613100 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature