IL-33 drives the production of mouse regulatory T cells with enhanced in vivo suppressive activity in skin transplantation.

ABSTRACT: Regulatory T cells (Tregs) are crucial mediators of immune homeostasis with the ability to modulate allogeneic response and control transplant rejection. Although Treg-based cell therapies have shown immense promise, methods to optimize current strategies are critical for successful implementation within the clinic. IL-33 is a cytokine with pleiotropic properties and effects on Treg function and development. In this study, we explored the unique properties of Treg populations activated through the IL-33/ST2 pathway, aiming to exploit their tolerogenic properties for cell therapy. We show that treatment with exogenous IL-33 results in a generalized downregulation of genes critical to T cell biology together with an upregulation of Treg-associated genes. Tregs that develop in response to IL-

SUBMITTER: Kawai K 

PROVIDER: S-EPMC7613121 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature